Meta-Analysis of Rare Binary Adverse Event Data

Rare psychotropic adverse event of moxonidine.

Moxonidine is a centrally acting antihypertensive agent with high affinity to the imidazolinI1 receptor which induces peripheral sympathetic inhibition reflected by lowering of blood pressure and heart rate (Ernsberger et al. 1993). To a lesser extent it also binds to the α2-receptors whose activation is responsible for side-effects of central antihypertensive drugs such as sedation and dry mou...

Propylthiouracil Induced Vasculitis: A Rare Adverse Event

Diaphragmatic hernia: a rare adverse event of colonoscopy.

A 25-year-old man underwent diagnostic colonoscopy because of mild upper abdominal pain. He had no history of trauma. The colonoscopy was completed without any significant difficulty. During the procedure, the patient did not complain of any pain or uncomfortable feelings. However, 24 hours after the procedure, the patient returned to the hospital with complaints of serious upper abdominal pain...

Patient Safety Culture: A Meta-analysis of Hospital Data

Background and Objectives: Patient safety (PS) is one of the most important and essential elements of quality in healthcare setting. A systematic review and meta-analysis was performed to assess the status of patient safety culture using the Hospital Survey on Patient Safety Culture (HSOPSC). Methods: In this systematic review and meta-analysis study, data were collected through searching dat...

Standardizing adverse drug event reporting data

BACKGROUND The Adverse Event Reporting System (AERS) is an FDA database providing rich information on voluntary reports of adverse drug events (ADEs). Normalizing data in the AERS would improve the mining capacity of the AERS for drug safety signal detection and promote semantic interoperability between the AERS and other data sources. In this study, we normalize the AERS and build a publicly a...